Amid ongoing trade talks between the EU and the US, the American Chamber of Commerce to the EU (AmCham EU) published its new recommendations to advance transatlantic economic cooperation in November 2018. The paper details a comprehensive set of opportunities for cooperation in the near and longer terms, focusing on areas such as pharmaceuticals, energy and the digital economy. From tackling unfair trading practices to strengthening regulatory cooperation, the two regions should build on the recent political momentum to enhance their economic ties, reinforce the global trading system and set world-leading standards.